3Scan is an automated histology company. Our core technical offering is a 3d imaging microscope, which generate volumetric image data. Each microscope can create several terabyte scale datasets per day, and we run 3 in production, and will have close to 10 by the end of the year. In this talk I will address some of the challenges and issues surrounding data collection and analysis at this scale. Relevant tools include, Python, Apache Spark, EC2, and Meteor.